Evidence of functional cross - talk between the Notch and NF - κ B pathways in non - neoplastic 1 hyperproliferating colonic epithelium

1 Evidence of functional cross-talk between the Notch and NF-κB pathways in non-neoplastic 1 hyperproliferating colonic epithelium 2 3 4 Ishfaq Ahmed, Badal Roy, Parthasarathy Chandrakesan, Anand Venugopal, Lijun 5 Xia, Roy Jensen, Shrikant Anant, Shahid Umar 6 7 8 From Departments of Molecular and Integrative Physiology and Pathology and Laboratory 9 Medicine, University of Kansas Medical Center, Kansas City, KS, 66160; Department of 10 Internal Medicine, University of Oklahoma Health Sciences Center and Cardiovascular Biology 11 Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104. 12 13 14 Running Head: Functional Cross-talk between Notch and NF-κB 15 16 17 18 Address for Correspondence: Shahid Umar, PhD, Associate Professor, Member – University of 19 Kansas Cancer Center, University of Kansas Medical Center, 3901 Rainbow Blvd, 4028 Wahl 20 Hall East, Kansas City, KS, 66160, USA, Phone: (913) – 945-6337, Fax: (913) – 945-6327, E21 mail: [email protected] 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (November 29, 2012). doi:10.1152/ajpgi.00372.2012